Invention Grant
US09383364B2 Predictive marker of DNMT1 inhibitor therapeutic efficacy and methods of using the marker
有权
DNMT1抑制剂的预测标记治疗效果及使用标记的方法
- Patent Title: Predictive marker of DNMT1 inhibitor therapeutic efficacy and methods of using the marker
- Patent Title (中): DNMT1抑制剂的预测标记治疗效果及使用标记的方法
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Application No.: US14003714Application Date: 2012-03-07
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Publication No.: US09383364B2Publication Date: 2016-07-05
- Inventor: Paula J. Bates , Mohammad Tariq Malik , Francesca R. Salipur
- Applicant: Paula J. Bates , Mohammad Tariq Malik , Francesca R. Salipur
- Applicant Address: US KY Louisville
- Assignee: University of Louisville Research Foundation, Inc.
- Current Assignee: University of Louisville Research Foundation, Inc.
- Current Assignee Address: US KY Louisville
- Agency: Calfee, Halter & Griswold LLP
- Agent Harry J. Guttman
- International Application: PCT/US2012/027982 WO 20120307
- International Announcement: WO2012/122219 WO 20120913
- Main IPC: A61K31/215
- IPC: A61K31/215 ; A61K31/22 ; G01N33/574 ; C12Q1/68 ; A61K31/045 ; C07K16/18 ; G01N33/53

Abstract:
Provided herein are methods for predicting efficacy of a DNA (cytosine-5)-methyltransferase 1 (DNMT1) inhibitor treatment in a subject having a cancer, methods of identifying a subject having a cancer that is more likely to respond to a DNMT1 inhibitor treatment, and methods of selecting a treatment for a subject having a cancer that include determining a level of SOX9 in a sample containing cells from a subject having a cancer. Also provided are methods of treating a subject having a cancer that include selectively administering a DNMT1 inhibitor to a subject having cancer determined to have an elevated level of SOX9 in a sample containing cells from the subject compared to a reference level. Also provided are antibodies and antigen-binding antibody fragments that specifically bind to SOX9, and nucleic acid sequences that contain at least 10 nucleotides complementary to a contiguous sequence present in a SOX9 nucleic acid for use in these methods.
Public/Granted literature
- US20140329911A1 PREDICTIVE MARKER OF DNMT1 INHIBITOR THERAPEUTIC EFFICACY AND METHODS OF USING THE MARKER Public/Granted day:2014-11-06
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