Invention Grant
US09383364B2 Predictive marker of DNMT1 inhibitor therapeutic efficacy and methods of using the marker 有权
DNMT1抑制剂的预测标记治疗效果及使用标记的方法

Predictive marker of DNMT1 inhibitor therapeutic efficacy and methods of using the marker
Abstract:
Provided herein are methods for predicting efficacy of a DNA (cytosine-5)-methyltransferase 1 (DNMT1) inhibitor treatment in a subject having a cancer, methods of identifying a subject having a cancer that is more likely to respond to a DNMT1 inhibitor treatment, and methods of selecting a treatment for a subject having a cancer that include determining a level of SOX9 in a sample containing cells from a subject having a cancer. Also provided are methods of treating a subject having a cancer that include selectively administering a DNMT1 inhibitor to a subject having cancer determined to have an elevated level of SOX9 in a sample containing cells from the subject compared to a reference level. Also provided are antibodies and antigen-binding antibody fragments that specifically bind to SOX9, and nucleic acid sequences that contain at least 10 nucleotides complementary to a contiguous sequence present in a SOX9 nucleic acid for use in these methods.
Information query
Patent Agency Ranking
0/0