A wireless device receives control message(s) comprising parameters of a plurality of cell groups and a pathloss reference for each secondary cell. The wireless device transmits uplink signals in a first secondary cell in a secondary cell group. Transmission power of the uplink signals is determined employing a received power of the pathloss reference assigned to the first secondary cell. Timing of the uplink signals in the secondary cell group employs a synchronization signal on an active secondary cell in the secondary cell group as a timing reference.