Invention Grant
- Patent Title: Methods and compositions for the inhibition of fructokinase
- Patent Title (中): 用于抑制果糖激酶的方法和组合物
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Application No.: US13814568Application Date: 2011-08-08
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Publication No.: US09387245B2Publication Date: 2016-07-12
- Inventor: Richard J. Johnson , Miguel A. Lanaspa-Garcia , Takuji Ishimoto
- Applicant: Richard J. Johnson , Miguel A. Lanaspa-Garcia , Takuji Ishimoto
- Applicant Address: US CO Denver
- Assignee: University of Colorado, A Body Corporate
- Current Assignee: University of Colorado, A Body Corporate
- Current Assignee Address: US CO Denver
- Agency: Beusse, Wolter, Sanks & Maire, PLLC
- Agent Timothy H. Van Dyke
- International Application: PCT/US2011/046938 WO 20110808
- International Announcement: WO2012/019188 WO 20120209
- Main IPC: A61K45/06
- IPC: A61K45/06 ; A61K38/00 ; C12N15/113 ; A61K39/395 ; C07K16/40 ; A61K31/415 ; A61K31/7052 ; A61K31/427 ; C12N9/12 ; A61K31/425
Abstract:
The invention relates to the use of isoform-specific fructokinase (ketohexokinase) (KHK) inhibitors alone or in combination with various agents to both prevent and treat a wide variety of diseases including, but not limited to, sugar craving, obesity, features of metabolic syndrome (including insulin resistance, hypertriglyceridemia, hypertension, and fatty liver), polyuria, proximal tubular injury, and diabetic kidney disease.
Public/Granted literature
- US20130224218A1 Methods and Compositions for the Inhibition of Fructokinase Public/Granted day:2013-08-29
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