Invention Grant
US09388136B2 Tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl]-L-alaninate or a salt, hydrate or solvate thereof 有权
N- [2- {4- [6-氨基-5-(2,4-二氟苯甲酰基)-2-氧代吡啶-1(2H) - 基] -3,5-二氟苯基}乙基] -L-丙氨酸叔丁酯 或其盐,水合物或溶剂合物

  • Patent Title: Tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl]-L-alaninate or a salt, hydrate or solvate thereof
  • Patent Title (中): N- [2- {4- [6-氨基-5-(2,4-二氟苯甲酰基)-2-氧代吡啶-1(2H) - 基] -3,5-二氟苯基}乙基] -L-丙氨酸叔丁酯 或其盐,水合物或溶剂合物
  • Application No.: US14436404
    Application Date: 2013-10-15
  • Publication No.: US09388136B2
    Publication Date: 2016-07-12
  • Inventor: Stéphane PintatStephen John DaviesDavid Festus Charles Moffat
  • Applicant: Chroma Therapeutics Ltd.
  • Applicant Address: GB Abingdon, Oxfordshire
  • Assignee: Chroma Therapeutics Ltd
  • Current Assignee: Chroma Therapeutics Ltd
  • Current Assignee Address: GB Abingdon, Oxfordshire
  • Agency: Norton Rose Fulbright US LLP
  • Priority: GB1218640.9 20121017; GB1306881.2 20130416
  • International Application: PCT/GB2013/052689 WO 20131015
  • International Announcement: WO2014/060742 WO 20140424
  • Main IPC: C07D213/73
  • IPC: C07D213/73 A61K31/4412
Tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl]-L-alaninate or a salt, hydrate or solvate thereof
Abstract:
The present invention provides a compound which is: tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl)-L-alaninate or a salt, hydrate or solvate thereof. The present invention also provides a pharmaceutical composition comprising the compound together with one or more pharmaceutically acceptable carriers and/or excipients. The compound and composition are useful for inhibiting the activity of a p38 MAP kinase enzyme. As such they may be used in the treatment of a autoimmune or inflammatory disease, or a cell proliferative disease. In addition, the invention provides an acid produced by hydrolysis of the ester group of the compound of the invention. The acid is N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl)-L-alanine.
Information query
Patent Agency Ranking
0/0