Invention Grant
US09388136B2 Tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl]-L-alaninate or a salt, hydrate or solvate thereof
有权
N- [2- {4- [6-氨基-5-(2,4-二氟苯甲酰基)-2-氧代吡啶-1(2H) - 基] -3,5-二氟苯基}乙基] -L-丙氨酸叔丁酯 或其盐,水合物或溶剂合物
- Patent Title: Tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl]-L-alaninate or a salt, hydrate or solvate thereof
- Patent Title (中): N- [2- {4- [6-氨基-5-(2,4-二氟苯甲酰基)-2-氧代吡啶-1(2H) - 基] -3,5-二氟苯基}乙基] -L-丙氨酸叔丁酯 或其盐,水合物或溶剂合物
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Application No.: US14436404Application Date: 2013-10-15
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Publication No.: US09388136B2Publication Date: 2016-07-12
- Inventor: Stéphane Pintat , Stephen John Davies , David Festus Charles Moffat
- Applicant: Chroma Therapeutics Ltd.
- Applicant Address: GB Abingdon, Oxfordshire
- Assignee: Chroma Therapeutics Ltd
- Current Assignee: Chroma Therapeutics Ltd
- Current Assignee Address: GB Abingdon, Oxfordshire
- Agency: Norton Rose Fulbright US LLP
- Priority: GB1218640.9 20121017; GB1306881.2 20130416
- International Application: PCT/GB2013/052689 WO 20131015
- International Announcement: WO2014/060742 WO 20140424
- Main IPC: C07D213/73
- IPC: C07D213/73 ; A61K31/4412
![Tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl]-L-alaninate or a salt, hydrate or solvate thereof](/abs-image/US/2016/07/12/US09388136B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides a compound which is: tert-butyl N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl)-L-alaninate or a salt, hydrate or solvate thereof. The present invention also provides a pharmaceutical composition comprising the compound together with one or more pharmaceutically acceptable carriers and/or excipients. The compound and composition are useful for inhibiting the activity of a p38 MAP kinase enzyme. As such they may be used in the treatment of a autoimmune or inflammatory disease, or a cell proliferative disease. In addition, the invention provides an acid produced by hydrolysis of the ester group of the compound of the invention. The acid is N-[2-{4-[6-amino-5-(2,4-difluorobenzoyl)-2-oxopyridin-1(2H)-yl]-3,5-difluorophenyl}ethyl)-L-alanine.
Public/Granted literature
- US20150246883A1 TERT-BUTYL N-[2-ETHYL]-L-ALANINATE OR A SALT, HYDRATE OR SOLVATE THEREOF Public/Granted day:2015-09-03
Information query
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