Invention Grant
- Patent Title: Derivatives of celeboxib, use thereof and preparation thereof
- Patent Title (中): 塞来昔布的衍生物，其用途及其制备
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Application No.: US14005462Application Date: 2012-03-16
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Publication No.: US09388139B2Publication Date: 2016-07-12
- Inventor: Gary A. Piazza , Ashraf H. Abadi
- Applicant: Gary A. Piazza , Ashraf H. Abadi
- Applicant Address: EG Cairo US AL Birmingham
- Assignee: German University,Southern Research Institute
- Current Assignee: German University,Southern Research Institute
- Current Assignee Address: EG Cairo US AL Birmingham
- Agency: Polsinelli PC
- International Application: PCT/US2012/029328 WO 20120316
- International Announcement: WO2012/125884 WO 20120920
- Main IPC: C07D231/06
- IPC: C07D231/06 ; C07D231/12
Abstract:
Derivatives of celecoxib that lack cyclooxygenase inhibitory activity but have improved PDE5 inhibitory activity are provided along with pharmaceutical compositions containing them for the treatment or prevention of cancer. Such compounds are expected to have reduced toxicity compared with celecoxib and other cyclooxygenase inhibitors, and greater efficacy compared with conventional PDE5 inhibitors. Derivatives of celecoxib are also suitable for treating chronic inflammatory conditions, erectile dysfunction, pulmonary hypertension, congestive heart failure, and enhancement of cognitive function.
Public/Granted literature
- US20140171477A1 DERIVATIVES OF CELEBOXIB, USE THEREOF AND PREPARATION THEREOF Public/Granted day:2014-06-19
Information query
