Invention Grant
- Patent Title: Fused imidazole derivatives useful as IDO inhibitors
- Patent Title (中): 用作IDO抑制剂的熔融咪唑衍生物
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Application No.: US14794193Application Date: 2015-07-08
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Publication No.: US09388191B2Publication Date: 2016-07-12
- Inventor: Mario Mautino , Sanjeev Kumar , Jesse Waldo , Firoz Jaipuri , Tanay Kesharwani , Xiaoxia Zhang
- Applicant: NewLink Genetics Corporation
- Applicant Address: US IA Ames
- Assignee: NewLink Genetics Corporation
- Current Assignee: NewLink Genetics Corporation
- Current Assignee Address: US IA Ames
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07F9/6561
Abstract:
Presently provided are IDO inhibitors and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosuppression associated with an infectious disease.
Public/Granted literature
- US20160002249A1 Fused Imidazole Derivatives Useful as IDO Inhibitors Public/Granted day:2016-01-07
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