Invention Grant
- Patent Title: Benzimidazole derivatives as Kinase Inhibitors
- Patent Title (中): 苯并咪唑衍生物作为激酶抑制剂
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Application No.: US14654779Application Date: 2013-12-20
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Publication No.: US09388192B2Publication Date: 2016-07-12
- Inventor: Wojciech Czardybon , Krzysztof Brzózka , Michal Galezowski , Renata Windak , Mariusz Milik , Magdalena Zawadzka , Pawel Guzik , Ewelina Wincza , Marta Prokop , Katarzyna Wiklik , Aleksandra Sabiniarz , Wieslaw Marek Cholody , Raymond Horvath , Tomasz Rzymski
- Applicant: SELVITA SA
- Applicant Address: PL Kraków
- Assignee: Selvita S.A.
- Current Assignee: Selvita S.A.
- Current Assignee Address: PL Kraków
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Priority: GB1223265.8 20121221
- International Application: PCT/EP2013/077754 WO 20131220
- International Announcement: WO2014/096388 WO 20140626
- Main IPC: C07D235/24
- IPC: C07D235/24 ; C07D235/30 ; C07D235/06 ; C07D235/14 ; C07D401/04 ; C07D401/12 ; C07D403/04 ; C07D403/12 ; C07D413/04 ; C07D413/12 ; C07D487/08 ; C07D401/14 ; C07D403/14 ; C07D405/12
Abstract:
The present invention relates to derivatives of benzimidazoles of formula (I) as disclosed herein as well as pharmaceutical compositions comprising said derivatives. The derivates according to the present invention are serine/threonine and tyrosine kinase-inhibitors, particularly of PIM1-3- and DYRK1A-kinases and may particularly be used in the treatment of diseases linked to these kinases, such as e.g. leukemias, lymphomas, solid tumors and autoimmune disorders.
Public/Granted literature
- US20150336967A1 Novel Benzimidazole Derivatives as Kinase Inhibitors Public/Granted day:2015-11-26
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