Invention Grant
- Patent Title: Internalizing ErbB2 antibodies
- Patent Title (中): 内化ErbB2抗体
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Application No.: US14627773Application Date: 2015-02-20
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Publication No.: US09388244B2Publication Date: 2016-07-12
- Inventor: James D. D. Marks , Marie Alix Poul
- Applicant: The Regents of the University of California
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Quine Intellectual Property Law Group, P.C.
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/18 ; C07K16/28 ; C07K16/30 ; C07K17/06 ; C07K17/08 ; A61K47/48 ; C07K16/32 ; C12N15/86 ; A61K31/704 ; A61K9/00 ; A61K38/00
Abstract:
This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into the cell bearing the c-erbB2 marker. Chimeric molecules comprising the F5 and/or C1 antibodies attached to one or more effector molecules are also provided.
Public/Granted literature
- US20150239976A1 Internalizing ErbB2 Antibodies Public/Granted day:2015-08-27
Information query
