Invention Grant
- Patent Title: Modified oligonucleotides for telomerase inhibition
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Application No.: US14720466Application Date: 2015-05-22
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Publication No.: US09388415B2Publication Date: 2016-07-12
- Inventor: Sergei Gryaznov , Krisztina Pongracz
- Applicant: Geron Corporation
- Agency: Bozicevic, Field & Francis LLP
- Agent Carol L. Francis; Glenn J. Foulds
- Main IPC: A61K31/7052
- IPC: A61K31/7052 ; C12N5/00 ; C07H21/00 ; C12N15/113 ; A61K47/48 ; C07H21/02 ; C07H21/04 ; C07C233/18
Abstract:
Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.
Public/Granted literature
- US20150322437A1 Modified Oligonucleotides for Telomerase Inhibition Public/Granted day:2015-11-12
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