Invention Grant
US09388426B2 Methods and compositions for inactivating glutamine synthetase gene expression
有权
用于灭活谷氨酰胺合成酶基因表达的方法和组合物
- Patent Title: Methods and compositions for inactivating glutamine synthetase gene expression
- Patent Title (中): 用于灭活谷氨酰胺合成酶基因表达的方法和组合物
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Application No.: US14552174Application Date: 2014-11-24
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Publication No.: US09388426B2Publication Date: 2016-07-12
- Inventor: Pei-Qi Liu , Jeffrey C. Miller
- Applicant: Sangamo BioSciences, Inc.
- Applicant Address: US CA Richmond
- Assignee: Sangamo BioSciences, Inc.
- Current Assignee: Sangamo BioSciences, Inc.
- Current Assignee Address: US CA Richmond
- Agency: Pasternak Patent Law
- Agent Susan Abrahamson
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12N15/85 ; C07K14/00 ; C12N9/22 ; C12N9/00 ; C12P21/02
Abstract:
Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
Public/Granted literature
- US20150087067A1 METHODS AND COMPOSITIONS FOR INACTIVATING GLUTAMINE SYNTHETASE GENE EXPRESSION Public/Granted day:2015-03-26
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