Water-resistant waders may incorporate a waist lock system to reduce the likelihood of water entering the waders below the wearer's waist area while the waders are being worn during water-based activities, such as fishing or hunting. The waders may include a waist lock system formed of a ring of water-resistant material that may be firmly positioned around the waist area of the wearer such that it may create a flap and seal structure. If water reaches the top portion of the waist lock system, the waist lock system generally may prevent or at least minimize the water that may penetrate the waist lock system and enter the waders, particularly below the wearer's waist area, such as the wearer's feet and legs.