A method of making a blister sealing fixture which includes the selection of a card locating portion which has an annular wall which defines an annular recess closed by a removable bottom wall. A sealing insert portion having a cavity to receive a blister to be sealed is positioned on the bottom wall and is adapted to be moved to all positions within the recess. A sample or test card of the configuration of a production run to be handled by the sealing fixture is selected and to this card a sample or test blister is attached. The position of the blister on the card is determined by the user and has herein has at times been referred to as a desired position or location. This resulting positioning device is then placed over the recess with the test blister engaging the recess in the sealing insert.