Invention Grant
US09399068B2 Hetero-assembling, tunable, and injectable hydrogels for cell encapsulation
有权
异种组装，可调和可注射的水凝胶用于细胞包封
- Patent Title: Hetero-assembling, tunable, and injectable hydrogels for cell encapsulation
- Patent Title (中): 异种组装，可调和可注射的水凝胶用于细胞包封
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Application No.: US14690589Application Date: 2015-04-20
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Publication No.: US09399068B2Publication Date: 2016-07-26
- Inventor: Sarah C. Heilshorn , Widya Mulyasasmita , Lei Cai
- Applicant: The Board of Trustees of the Leland Stanford Junior University
- Applicant Address: US CA Palo Alto
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Palo Alto
- Agency: Lumen Patent Firm
- Main IPC: A61K47/42
- IPC: A61K47/42 ; A61K9/00 ; C12N5/00
Abstract:
A viscoelastic hydrogel based on a protein hetero-assembled with a polymer is provided. The protein cannot self-assemble with itself and the polymer cannot self-assemble with itself. The protein has a first association sequence (1stA) and a first spacer (1stSp). The polymer has a second association sequence (2ndA) and a second spacer (2ndSp). The first association sequence and the second association sequence are physically cross-linked to interact with each other with a 1:1 known and specific stoichiometry to form a three dimensional scaffold. The protein is represented by {1stA(1stSp)}x1stA, where x is ≧2, and the polymer is represented by {2ndA(2ndSp)}y2ndA, where y≧2.
Public/Granted literature
- US20150290329A1 Hetero-assembling, Tunable, and Injectable Hydrogels for Cell Encapsulation Public/Granted day:2015-10-15
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