A device for making nano-scale particles of titanium dioxide includes a vacuum chamber; an evaporator, a gas supplier, a vacuum pump assembly, and a product collecting device. The evaporator is mounted in the vacuum chamber. The gas supplier communicates with the vacuum chamber. The vacuum pump assembly communicates with the vacuum chamber. The product collecting device includes a pump, a guide pipe connected with the pump, and a powder collector communicating with the guide pipe. The pump communicates with the vacuum chamber. The guide pipe is inserted in the powder collector, the powder collector is filled with organic solvents. A method of making nano-scale particles of titanium dioxide using the device is also provided.