Invention Grant
US09399624B2 Process for preparing (1S)-1-phenyl-3,4-dihydro-2(1H)-isoquinoline-carboxylate
有权
制备（1S）-1-苯基-3,4-二氢-2（1H） - 异喹啉羧酸酯的方法
- Patent Title: Process for preparing (1S)-1-phenyl-3,4-dihydro-2(1H)-isoquinoline-carboxylate
- Patent Title (中): 制备（1S）-1-苯基-3,4-二氢-2（1H） - 异喹啉羧酸酯的方法
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Application No.: US14690282Application Date: 2015-04-17
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Publication No.: US09399624B2Publication Date: 2016-07-26
- Inventor: Yue Huang , Fei Zheng
- Applicant: Shanghai Jingxin Biomedical Co., Ltd. , Shangyu Jingxin Pharmaceutical Co., Ltd.
- Applicant Address: CN Shanghai CN Shangyu
- Assignee: Shanghai Jingxin Biomedical Co., Ltd.,Shangyu Jingxin Pharmaceutical Co., Ltd.
- Current Assignee: Shanghai Jingxin Biomedical Co., Ltd.,Shangyu Jingxin Pharmaceutical Co., Ltd.
- Current Assignee Address: CN Shanghai CN Shangyu
- Agency: Mei & Mark LLP
- Agent Manni Li
- Priority: CN201210425678 20121030
- Main IPC: C07D217/06
- IPC: C07D217/06 ; C07D453/02
Abstract:
A process for preparation of (1S)-1-phenyl-3,4-dihydro-2(1H)-isoquinoline-carboxylate (Formula I), comprising reacting (1S)-1-phenyl-3,4-dihydro-2(1H)isoquinoline (Formula II) with carbon dioxide and an alkylating agent R-LG in the presence of a base to obtain the compound of Formula I in an organic solvent. In Formula I and II, R is an alkyl or a substituted alkyl; LG is a leaving group.
Public/Granted literature
- US20150225348A1 PROCESS FOR PREPARING (1S)-1-PHENYL-3,4-DIHYDRO-2(1H)-ISOQUINOLINE-CARBOXYLATE Public/Granted day:2015-08-13
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