Invention Grant
US09399641B2 Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates
有权
吡咯并苯并二氮杂卓作为不对称二聚体PBD化合物包含在目标缀合物中
- Patent Title: Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates
- Patent Title (中): 吡咯并苯并二氮杂卓作为不对称二聚体PBD化合物包含在目标缀合物中
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Application No.: US14346006Application Date: 2012-09-20
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Publication No.: US09399641B2Publication Date: 2016-07-26
- Inventor: Philip Wilson Howard
- Applicant: MEDIMMUNE LIMITED
- Applicant Address: GB Cambridge
- Assignee: MEDIMMUNE LIMITED
- Current Assignee: MEDIMMUNE LIMITED
- Current Assignee Address: GB Cambridge
- Agency: Michael Best & Friedrich LLP
- International Application: PCT/EP2012/068506 WO 20120920
- International Announcement: WO2013/041606 WO 20130328
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D519/00 ; A61K47/48 ; C07K5/062 ; C07K5/065 ; C07K5/078
Abstract:
A compound with the formula I wherein: R2 is of formula II where Q is selected from OH, SH and NRN, and RN is selected from H, methyl and ethyl, as well as drug-linkers and drug-conjugates made from this compound.
Public/Granted literature
- US09266894B2 Pyrrolobenzodiazepines as unsymmetrical dimeric PBD compounds for inclusion in targeted conjugates Public/Granted day:2016-02-23
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