Invention Grant
US09399775B2 RNAi agents, compositions and methods of use thereof for treating transthyretin (TTR) associated diseases
有权
RNAi剂，其组合物及其用于治疗转甲状腺素蛋白（TTR）相关疾病的方法
- Patent Title: RNAi agents, compositions and methods of use thereof for treating transthyretin (TTR) associated diseases
- Patent Title (中): RNAi剂，其组合物及其用于治疗转甲状腺素蛋白（TTR）相关疾病的方法
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Application No.: US14358972Application Date: 2012-11-16
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Publication No.: US09399775B2Publication Date: 2016-07-26
- Inventor: Kallanthottathil G. Rajeev , Tracy Zimmermann , Muthiah Manoharan , Martin Maier , Satyanarayana Kuchimanchi , Klaus Charisse
- Applicant: Alnylam Pharmaceuticals, Inc.
- Applicant Address: US MA Cambridge
- Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee: Alnylam Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: McCarter & English, LLP
- Agent Maria Laccotripe Zacharakis; Deborah L. Nagle
- International Application: PCT/US2012/065691 WO 20121116
- International Announcement: WO2013/075035 WO 20130523
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C07H21/02 ; A61K31/7125 ; A61K31/713
Abstract:
The present invention provides RNAi agents, e.g., double stranded RNAi agents, that target the transthyretin (TTR) gene and methods of using such RNAi agents for treating or preventing TTR-associated diseases.
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