Invention Grant
- Patent Title: Detection/measurement of malaria infection disease utilizing natural immunity by hemozoin induction, screening of preventative or therapeutic medicine for malaria infection disease, and regulation of natural immunity induction
- Patent Title (中): 通过血红素诱导自然免疫的疟疾感染疾病的检测/测量，疟疾感染疾病的预防或治疗药物的筛选和天然免疫诱导的调节
-
Application No.: US13312260Application Date: 2011-12-06
-
Publication No.: US09400279B2Publication Date: 2016-07-26
- Inventor: Shizuo Akira , Ken Ishii , Cevayir Coban
- Applicant: Shizuo Akira , Ken Ishii , Cevayir Coban
- Applicant Address: JP Osaka
- Assignee: Osaka University
- Current Assignee: Osaka University
- Current Assignee Address: JP Osaka
- Agency: Foley & Lardner LLP
- Priority: JP2004-357255 20041209
- Main IPC: A61K31/555
- IPC: A61K31/555 ; A61K38/02 ; C12N5/071 ; G01N33/569
Abstract:
The instant invention is to provide a method for detecting and measuring malaria infection utilizing the induction by hemozoin (HZ); a method for screening a vaccine for malaria infection and a preventative or therapeutic agent for malaria infection using the method for detecting and measuring; and a means for regulating the induction of innate immunity using the HZ, synthetic HZ, or derivatives thereof as an adjuvant or immunostimulant. Malaria infection is detected and measured of by detecting and measuring HZ-induced, TLR9-mediated, and MyD88-dependent innate immune activity. The detection and measurement of malaria infection can be used to diagnose malaria infection. The method for detecting and measuring is also used for screening a vaccine for malaria infection and a preventative or therapeutic agent for malaria infection. Further, HZ, synthetic HZ, or derivatives thereof are used as an adjuvant or immunostimulant to regulate HZ-induced innate immune induction.
Public/Granted literature
Information query
