Described systems and methods enable a host system to efficiently perform computer security activities, when operating in a hardware virtualization configuration. A hypervisor exposes a virtual machine on the host system. In some embodiments, the hypervisor further configures a processor of the host system to generate a virtualization exception in response to detecting a memory access violation, and to deliver such exceptions to a computer security program operating within the virtual machine. The hypervisor may further set access permissions to a section of memory containing a part of a function targeted for hooking, so that an attempt to execute the respective target function triggers a virtualization exception. Some embodiments thus achieve hooking of the target function without resorting to conventional methods, such as patching, inline hooking, and MSR hooking.