A system and method for use in one or more casino establishments for offering a game of chance with multiple wheels. A player may bet on one or more of the wheels to win an award. The resulting pay is based on the combination of the final position of the wheels after they come to a stop. The award may be the cumulative value for winning outcomes on each of the wheels, it may be a set outcome depending on the combination of symbols on a win line across the wheels, or it may include special awards such as multipliers and wild card wins depending on the wheel configuration. The system and method are offered on an electronic multi-wheel gaming system with multiple player terminals connected to a set of electro-mechanical wheels or video wheels displayed on a screen, but may also be deployed in other forms such as on a live table game with a live operator of mechanical wheels, or on a general purpose computing device connected to a network.