According to one embodiment, a system for selecting an optimum tape layout to store data on a tape medium includes a processor and logic integrated with and/or executable by the processor, the logic being configured to compute a set of all minimum distances corresponding to a plurality of data set layouts, wherein each minimum distance is computed between a location of a first codeword interleave (CWI) and locations of all other CWIs in a common sub data set (SDS), and calculate a first performance metric associated with each possible set of parameters using the set of all minimum distances for the plurality of data set layouts, the parameters being associated with at least a tape drive and the tape medium. More systems, methods, and computer program products for selecting optimum tape layouts to store data on tape media are described in accordance with other embodiments.