The present invention provides an overvoltage protection circuit, an overvoltage protection method and a panel driving circuit, wherein, the overvoltage protection circuit adjusts drive output voltage of LED strings coupled with a main IC and a secondary IC and includes a main IC overvoltage triggering circuit and a secondary IC overvoltage triggering circuit, wherein, the main IC overvoltage triggering circuit connected respectively in series with said main IC and several LED strings, said secondary IC overvoltage triggering circuit connected respectively in series with the secondary IC and several LED strings, overvoltage protection triggering points are set respectively in the main IC and the secondary IC, and the voltage value of the overvoltage protection's triggering point of the secondary IC is less than that of the main IC.