A robust and fast background calibration technique for correction of time-interleaved ADC offset, gain, bandwidth, and timing mismatches is proposed. The technique combines the use of a calibration signal and a reference ADC. The calibration signal enhances robustness and makes the technique independent of the input signal's statistics. The reference ADC speeds up convergence and enables the use of a small amplitude calibration signal that does not significantly reduce the input signal dynamic range. The calibration signal can be subtracted or filtered from the ADC output and is therefore invisible to the ADC user.