A method of closed-loop antenna tuning (CLAT) search strategy based on maximum Relative Transducer Gain (RTG) is proposed. A search region that account for TX input mismatch and forward voltage gain is pre-computed. The search region that is independent of antenna load can be pre-computed to reduce the computation complexity. The Maximum RTG is searched by estimating antenna S-parameters corresponding to a good load match. The search is conducted between the peak forward voltage gain and the best load match. Global optimal with reasonable RTG can be found with limited number of iterations. The transmitter search region can further be constrained by the receiver path mismatching.