Systems for performing inline wire speed data deduplication are described herein. Some embodiments include a device for inline data deduplication that includes one or more input ports for receiving an input data stream containing duplicates, one or more output ports for providing a data deduplicated output data stream, and an inline data deduplication engine coupled to one or more input ports and one or more output ports to process input data containing duplicates into output data which is data deduplicated, where the inline data deduplication engine has an inline data deduplication bandwidth of at least 4 Gigabytes per second.