Embodiments of a distributed antenna system (DAS) and method for enhanced positioning in a wireless network are generally described herein. In some embodiments, an enhanced Node-B (eNB) operates as part of a DAS that includes one or more nodes having the same cell ID as the eNB. The eNB is to transmit a UE-specific reference signal and configure one or more of the other nodes of the cell to transmit UE-specific reference signals that are distinguishable from each other and from the UE-specific reference signal that is transmitted by the eNB. The eNB may receive location estimate information from user equipment (UE) that is determined at least in part from the UE-specific reference signals. The eNB may also configure the nodes to perform cooperative OFDMA transmission techniques for the UEs operating in the cell.