A coordinate system particular to a subject's tissue, such as a subject's brain, is provided. Furthermore, a system and method for multi-dimensional, interrelated tractography is provided. Images of the subject are acquired that include diffusion information and tracts and/or vectors potentially associated with tracts are determined therefrom. With respect to the coordinate system, this information is used along with an basis that the tracts and/or vectors generally conform to a substantially orthogonal grid, such that white matter tissue fibers are arranged as one of substantially parallel or substantially orthogonal to other fibers. This coordinate system may be provided to a user along with reconstructed images, or may be used to process images. Similarly, in multi-dimensional, interrelated tractography, a new predictive ability and new metrics are provided along with an improved ability to reconstructed or process images.