Invention Grant
US09402820B2 Use of pyruvate or succinate to enhance the efficacy of a hypoxia activated prodrug for the treatment of tumors
有权
使用丙酮酸或琥珀酸盐来增强缺氧活化前体药物治疗肿瘤的功效
- Patent Title: Use of pyruvate or succinate to enhance the efficacy of a hypoxia activated prodrug for the treatment of tumors
- Patent Title (中): 使用丙酮酸或琥珀酸盐来增强缺氧活化前体药物治疗肿瘤的功效
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Application No.: US14112906Application Date: 2012-04-20
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Publication No.: US09402820B2Publication Date: 2016-08-02
- Inventor: Shingo Matsumoto , Robert J. Gillies , James B. Mitchell , Murali K. Cherukuri , Keita Saito
- Applicant: Shingo Matsumoto , Robert J. Gillies , James B. Mitchell , Murali K. Cherukuri , Keita Saito
- Applicant Address: US DC Washington US FL Tampa
- Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES,H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
- Current Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES,H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.
- Current Assignee Address: US DC Washington US FL Tampa
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2012/034534 WO 20120420
- International Announcement: WO2012/145684 WO 20121026
- Main IPC: A61K31/19
- IPC: A61K31/19 ; A61K45/06 ; A61K31/355
Abstract:
The identification of pO2 lowering agents as transient hypoxia-inducers is disclosed herein. Provided is a method of enhancing the efficacy of a hypoxia-sensitive agent in a subject, by administering to the subject a therapeutically effective amount of the hypoxia-sensitive agent and a therapeutically effective amount of a pO2 lowering agent. Methods of treating a subject with a tumor, by administering to the subject a therapeutically effective amount of a pO2 lowering agent and a therapeutically effective amount of a hypoxia-sensitive agent are also disclosed.
Public/Granted literature
- US20140045796A1 TRANSIENT HYPOXIA INDUCERS AND THEIR USE Public/Granted day:2014-02-13
Information query
