Invention Grant
- Patent Title: Method of treating and preventing secondary hyperparathyroidism
- Patent Title (中): 治疗和预防继发性甲状旁腺功能亢进的方法
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Application No.: US13680997Application Date: 2012-11-19
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Publication No.: US09402855B2Publication Date: 2016-08-02
- Inventor: Charles W. Bishop , Keith H. Crawford , Eric J. Messner , P. Martin Petkovich , Christian F. Helvig
- Applicant: CYTOCHROMA INC. , PROVENTIV THERAPEUTICS, LLC
- Applicant Address: US FL Miami KY Grand Cayman
- Assignee: OPKO RENAL, LLC,OPKO IRELAND GLOBAL HOLDINGS, LTD.
- Current Assignee: OPKO RENAL, LLC,OPKO IRELAND GLOBAL HOLDINGS, LTD.
- Current Assignee Address: US FL Miami KY Grand Cayman
- Agency: Marshall, Gerstein & Borun LLP
- Main IPC: A61K31/59
- IPC: A61K31/59 ; A61K31/593 ; A61K31/592

Abstract:
The method of treating elevated blood levels of iPTH by increasing or maintaining blood concentrations of both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in a patient by administering, as necessary, both Vitamin D repletion and Vitamin D hormone replacement therapies, is disclosed. The blood concentrations of 25-hydroxyvitamin D are increased to and maintained at or above 30 ng/mL, and blood concentrations of 1,25-dihydroxyvitamin D are increased to or maintained within a patient's normal historical physiological range for 1,25-dihydroxyvitamin D without causing substantially increased risk of hypercalcemia, hyperphosphatemia or over suppression of plasma iPTH in the patient. The blood levels of 25-hydroxyvitamin D are maintained at or above 30 ng/mL between doses of Vitamin D repletion therapies, and the blood levels of 1,25-dihydroxyvitamin D are maintained in the patient's normal historical physiological range between doses of Vitamin D hormone replacement therapies. In one aspect, the disclosure includes methods wherein the blood concentration of 25-hydroxyvitamin D during treatment comprises predominantly 25-hydroxyvitamin D3, and/or wherein the method includes administering predominantly or solely 25-hydroxyvitamin D3 for 25-hydroxyvitamin D repletion and/or maintenance.
Public/Granted literature
- US20130178451A1 METHOD OF TREATING AND PREVENTING SECONDARY HYPERPARATHYROIDISM Public/Granted day:2013-07-11
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