Invention Grant
- Patent Title: Pharmaceutical dosage form comprising polymeric carrier composition
- Patent Title (中): 包含聚合物载体组合物的药物剂型
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Application No.: US14152567Application Date: 2014-01-10
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Publication No.: US09402909B2Publication Date: 2016-08-02
- Inventor: Bernd Liepold , Jörg Breitenbach , Markus Mägerlein , Claudia Henzel , Thomas K. Kessler
- Applicant: Abbvie Deutschland GmbH & Co. KG
- Applicant Address: DE Wiesbaden
- Assignee: Abbvie Deutschland GmbH & Co KG
- Current Assignee: Abbvie Deutschland GmbH & Co KG
- Current Assignee Address: DE Wiesbaden
- Agency: Saul Ewing LLP
- Agent Peter C. Lauro, Esq.
- Priority: EP08159367 20080630
- Main IPC: A61K47/32
- IPC: A61K47/32 ; A61K9/20

Abstract:
A pharmaceutical dosage form comprises a solid dispersion product of at least one active ingredient dispersed in a polymeric binder composition, the polymeric carrier composition comprising a) a vinylpyrrolidone homopolymer, wherein at least 95% by weight of the vinylpyrrolidone homopolymer has a molecular weight distribution within the range of from 1000 to 13 000; and b) a vinylpyrrolidone copolymer having a weight-average molecular weight of from 5000 to 1 500 000. The dosage form is preferably prepared by a melt extrusion process. The polymeric carrier composition exhibits a high drug dissolution power and allows a reduction of the viscosity of the melt without deteriorating the mechanical properties and storage stability of the dosage form.
Public/Granted literature
- US20140200278A1 PHARMACEUTICAL DOSAGE FORM COMPRISING POLYMERIC CARRIER COMPOSITION Public/Granted day:2014-07-17
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