Invention Grant
US09403001B2 Non-invasive magnetic or electrical nerve stimulation to treat gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders
有权
非侵入性磁力或电神经刺激治疗胃轻瘫,功能性消化不良和其他功能性胃肠道疾病
- Patent Title: Non-invasive magnetic or electrical nerve stimulation to treat gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders
- Patent Title (中): 非侵入性磁力或电神经刺激治疗胃轻瘫,功能性消化不良和其他功能性胃肠道疾病
-
Application No.: US13731035Application Date: 2012-12-30
-
Publication No.: US09403001B2Publication Date: 2016-08-02
- Inventor: Bruce J. Simon , Joseph P. Errico , John T. Raffle
- Applicant: Electrocore, LLC
- Applicant Address: US NJ Basking Ridge
- Assignee: Electrocore, LLC
- Current Assignee: Electrocore, LLC
- Current Assignee Address: US NJ Basking Ridge
- Agency: Dentons US LLP
- Main IPC: A61N1/36
- IPC: A61N1/36 ; A61N1/40 ; A61N2/00 ; A61N2/02 ; A61N1/20 ; A61N1/04

Abstract:
Devices, systems and methods are disclosed for treating or preventing gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The methods provide damaged interstitial cells of Cajal (ICC) with trophic factors via vagal afferent nerve fibers, thereby reversing ICC damage, and as a consequence improving gastric motility. The methods also increase levels of inhibitory neurotransmitters in the brain so as to decrease neural activity within the area postrema, or they deactivate a resting state neural network containing parts of the anterior insula and anterior cingulate cortex, which will thereby reduce abnormal interoception and visceral hypersensitivity.
Public/Granted literature
Information query