A waterproof hermetically-sealed electronic product protection device includes a body and at least a covering element. The body has a receiving space and at least an opening in communication with the receiving space. The body has a positioning section at the periphery of the at least an opening. The at least a covering element has a protective portion and an engaging portion circumferentially disposed at the periphery of the protective portion. The engaging portion is engaged with the positioning section of the body, such that the at least a covering element covers the at least an opening, and the receiving space is airtight. Hence, not only is the engaging portion engaged with and fixed to the positioning section, but the receiving space is also waterproof and airtight to thereby provide electronic product protection and enable users to operate an electronic product with the protective portion directly.