The invention relates to a rotary-spindle syringe, comprising a rotary element (24) with a thread which is in threaded engagement with the driver (40) wherein the driver (40) acts on a piston (16) and is mounted in a translationally moveable manner relative to the latter, and the rotary-spindle syringe (10) discharges material upon actuation of the rotary element (24) as well as upon application of pressure to a hand support (50) of the piston (16) or a plunger (62) of the piston (16).