Invention Grant
- Patent Title: Preparation of intermediates of X-ray contrast agents
- Patent Title (中): X射线造影剂中间体的制备
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Application No.: US14437430Application Date: 2013-10-24
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Publication No.: US09403757B2Publication Date: 2016-08-02
- Inventor: Torfinn Haaland
- Applicant: GE Healthcare AS
- Applicant Address: NO Nycoveien
- Assignee: GE Healthcare AS
- Current Assignee: GE Healthcare AS
- Current Assignee Address: NO Nycoveien
- Priority: EP12192193 20121112
- International Application: PCT/US2013/066487 WO 20131024
- International Announcement: WO2014/074315 WO 20140515
- Main IPC: C07C237/46
- IPC: C07C237/46 ; A61K49/04 ; C07C231/12 ; C07C231/14
Abstract:
The present invention relates to a process for the preparation of iodinated X-ray contrast agents and in particular to key intermediates thereof. It particularly relates to an improved process for preparation of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (Compound A) or N,N′-bis(2,3-dihydroxypropyl)-5-formamido-2,4,6-triiodoisophthalamide (Compound C), which are intermediates in the industrial preparation of non-ionic X-ray contrast agents. More particularly the invention provides a process for deacylation of the acylated hydroxyl groups of an intermediate compound of Compound A and Compound C.
Public/Granted literature
- US20150274645A1 PREPARATION OF INTERMEDIATES OF X-RAY CONTRAST AGENTS Public/Granted day:2015-10-01
Information query
