Invention Grant
US09403769B2 Small molecule inhibitors of PFKFB3 and glycolytic flux and their methods of use as anti-cancer therapeutics
有权
PFKFB3和糖酵解助剂的小分子抑制剂及其作为抗癌治疗剂的方法
- Patent Title: Small molecule inhibitors of PFKFB3 and glycolytic flux and their methods of use as anti-cancer therapeutics
- Patent Title (中): PFKFB3和糖酵解助剂的小分子抑制剂及其作为抗癌治疗剂的方法
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Application No.: US13580558Application Date: 2011-02-22
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Publication No.: US09403769B2Publication Date: 2016-08-02
- Inventor: Pooran Chand , Jason A. Chesney , Brian F. Clem , Gilles H. Tapolsky , Sucheta Telang , John O. Trent
- Applicant: Pooran Chand , Jason A. Chesney , Brian F. Clem , Gilles H. Tapolsky , Sucheta Telang , John O. Trent
- Applicant Address: US KY Louisville US KY Louisville
- Assignee: Advanced Cancer Therapeutics, LLC,University of Louisville Research Foundation, Inc.
- Current Assignee: Advanced Cancer Therapeutics, LLC,University of Louisville Research Foundation, Inc.
- Current Assignee Address: US KY Louisville US KY Louisville
- Agency: Dinsmore & Shohl LLP
- International Application: PCT/US2011/025691 WO 20110222
- International Announcement: WO2011/103557 WO 20110825
- Main IPC: C07D209/60
- IPC: C07D209/60 ; C07D401/06 ; C07D471/04
Abstract:
Small molecule inhibitors of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) having the following formula: Formula (1) are provided herein. Also provided herein are pharmaceutical compositions containing Formula I compounds, together with methods of treating cancer, methods of inhibiting PFK.FB3 enzymatic activity, methods of inhibiting glycolytic flux, and methods of treating tumors by administering an effective amount of a Formula I compound.
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