Invention Grant
US09403772B2 4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium as a neurokinin receptor modulator
有权
-4-（5-（2-（3,5-双（三氟甲基）苯基）-N，2-二甲基丙酰胺基）-4-（邻甲苯基）吡啶-2-基）-1-甲基-1 - （（膦酰氧基 ）甲基）哌嗪-1-酮作为神经激肽受体调节剂
- Patent Title: 4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium as a neurokinin receptor modulator
- Patent Title (中): -4-（5-（2-（3,5-双（三氟甲基）苯基）-N，2-二甲基丙酰胺基）-4-（邻甲苯基）吡啶-2-基）-1-甲基-1 - （（膦酰氧基 ）甲基）哌嗪-1-酮作为神经激肽受体调节剂
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Application No.: US14360991Application Date: 2012-11-28
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Publication No.: US09403772B2Publication Date: 2016-08-02
- Inventor: Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J Stella
- Applicant: HELSINN HEALTHCARE SA
- Applicant Address: CH Lugano/Pazzallo
- Assignee: HELSINN HEALTHCARE SA
- Current Assignee: HELSINN HEALTHCARE SA
- Current Assignee Address: CH Lugano/Pazzallo
- Agent Clark G. Sullivan
- International Application: PCT/US2012/066778 WO 20121128
- International Announcement: WO2013/082102 WO 20130606
- Main IPC: C07D401/04
- IPC: C07D401/04 ; C07D213/74 ; C07D213/89 ; C07F9/06 ; C07D213/72 ; C07D213/76
Abstract:
Compounds and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor, based on 4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)3yridine-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium and pharmaceutically acceptable salts thereof.
Public/Granted literature
- US20150011510A1 SUBSTITUTED 4-PHENYL-PYRIDINES Public/Granted day:2015-01-08
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