Invention Grant
- Patent Title: AZA spiro alkane derivatives as inhibitors of metalloproteases
- Patent Title (中): AZA螺烷烷衍生物作为金属蛋白酶的抑制剂
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Application No.: US14092351Application Date: 2013-11-27
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Publication No.: US09403775B2Publication Date: 2016-08-02
- Inventor: Wenqing Yao , Jincong Zhuo , Meizhong Xu , Fenglei Zhang , Brian W. Metcalf
- Applicant: Incyte Corporation , Incyte Holdings Corporation
- Applicant Address: US DE Wilmington US DE Wilmington
- Assignee: Incyte Corporation,Incyte Holdings Corporation
- Current Assignee: Incyte Corporation,Incyte Holdings Corporation
- Current Assignee Address: US DE Wilmington US DE Wilmington
- Agency: Fish & Richardson P.C.
- Main IPC: A61K31/46
- IPC: A61K31/46 ; A61K31/497 ; A61K31/44 ; A61K31/495 ; A61K31/55 ; A61K31/4965 ; C07D221/10 ; C07D401/12 ; C07D401/14 ; C07D471/04 ; C07D487/04 ; C07D221/20 ; C07D401/06 ; C07D405/14 ; C07D409/14 ; C07D417/14 ; C07D495/04 ; C07D405/12
Abstract:
The present invention provides a compound of Formula I or Formula II: enantiomer, diastereomer, prodrug, solvate, metabolite, or pharmaceutically acceptable salt thereof, wherein constituent variables are provided herein. The compounds of Formula I and II are modulators of metalloproteases and are useful in treating diseases associated with metalloprotease activity such as arthritis, cancer, cardiovascular disorders, skin disorders, inflammation and allergic conditions.
Public/Granted literature
- US20140187530A1 AZA Spiro Alkane Derivatives as Inhibitors of Metalloproteases Public/Granted day:2014-07-03
Information query
