Invention Grant
- Patent Title: Triazinone compound and T-type calcium channel inhibitor
- Patent Title (中): 三嗪酮化合物和T型钙通道抑制剂
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Application No.: US14384875Application Date: 2013-03-29
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Publication No.: US09403798B2Publication Date: 2016-08-02
- Inventor: Noriko Saito , Jun Egi , Hiroshi Nagai , Megumi Ueno , Yusuke Shintani , Yusuke Inaba , Michiaki Adachi , Yuichi Hirai , Takeshi Kawazu , Koichi Yasutake , Daiki Takahashi
- Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.
- Applicant Address: JP Tokyo
- Assignee: NISSAN CHEMICAL INDUSTRIES, LTD.
- Current Assignee: NISSAN CHEMICAL INDUSTRIES, LTD.
- Current Assignee Address: JP Tokyo
- Agency: Oliff PLC
- Priority: JP2012-081163 20120330; JP2013-039267 20130228
- International Application: PCT/JP2013/059589 WO 20130329
- International Announcement: WO2013/147183 WO 20131003
- Main IPC: C07D251/26
- IPC: C07D251/26 ; C07D401/00 ; C07D403/00 ; C07D405/00 ; C07D409/00 ; C07D413/04 ; A61K31/53 ; A61P25/04 ; A61P25/08 ; C07D403/06 ; C07D403/12 ; C07D401/14 ; C07D401/04 ; C07D401/06 ; C07D401/12 ; C07D403/04 ; C07D405/06 ; C07D405/12 ; C07D409/06 ; C07D409/12 ; C07D409/14 ; C07D417/06 ; C07D251/46 ; C07D251/30 ; C07D251/42 ; C07D405/14 ; C07D417/14 ; C07D471/10 ; C07D487/18 ; C07D491/08

Abstract:
There is provided a novel triazinone compound that has an excellent T-type voltage-dependent calcium channel inhibitory activity and is specifically useful for treatment of pain. A compound of Formula (I), a tautomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof: where each substituent is defined in detail in the description or claims, for example R1 is H or C1-6 alkoxy, etc., each of L1 and L2 is independently a single bond or NR2, etc., L3 is C1-6 alkylene, etc., A is C6-14 aryl or 5 to 10-membered heteroaryl which is optionally substituted, etc., B is C3-11 cycloalkylene, etc., D is C6-14 aryl or 5 to 10-membered heteroaryl which is optionally substituted, etc.
Public/Granted literature
- US20150065705A1 TRIAZINONE COMPOUND AND T-TYPE CALCIUM CHANNEL INHIBITOR Public/Granted day:2015-03-05
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