Invention Grant
- Patent Title: Inhibitors of leukotriene production
- Patent Title (中): 抑制白三烯生产
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Application No.: US13942988Application Date: 2013-07-16
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Publication No.: US09403830B2Publication Date: 2016-08-02
- Inventor: Asitha Abeywardane , Steven Richard Brunette , Michael Jason Burke , Thomas Martin Kirrane, Jr. , Chuk Chui Man , Daniel Richard Marshall , Anil Kumar Padyana , Hossein Razavi , Robert Sibley , Lana Louise Smith Keenan , Roger John Snow , Ronald John Sorcek , Hidenori Takahashi , Steven John Taylor , Michael Robert Turner , Erick Richard Roush Young , Qiang Zhang , Yunlong Zhang , Renee M. Zindell
- Applicant: Asitha Abeywardane , Steven Richard Brunette , Michael Jason Burke , Thomas Martin Kirrane, Jr. , Chuk Chui Man , Daniel Richard Marshall , Anil Kumar Padyana , Hossein Razavi , Robert Sibley , Lana Louise Smith Keenan , Roger John Snow , Ronald John Sorcek , Hidenori Takahashi , Steven John Taylor , Michael Robert Turner , Erick Richard Roush Young , Qiang Zhang , Yunlong Zhang , Renee M. Zindell
- Applicant Address: DE Ingelheim am Rhein
- Assignee: Boehringer Ingelheim International GmbH
- Current Assignee: Boehringer Ingelheim International GmbH
- Current Assignee Address: DE Ingelheim am Rhein
- Agent Michael P. Morris; Usha R. Patel
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D401/14 ; C07D405/14 ; C07D413/14 ; C07D401/04 ; C07D401/12 ; C07D417/14 ; C07D471/04 ; C07D471/20 ; C07D491/20 ; A61K31/454 ; A61K31/4545 ; A61K31/496 ; A61K31/5377 ; A61K31/549 ; A61K31/55 ; A61K31/551 ; C07D405/12 ; C07D497/08 ; C07D498/04
Abstract:
The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein A1, A2, L1 and B are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
Public/Granted literature
- US20140031339A1 INHIBITORS OF LEUKOTRIENE PRODUCTION Public/Granted day:2014-01-30
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