Invention Grant
US09403855B2 Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses
有权
具有抗流感活性的Zanamivir膦酸酯同系物并测定流感病毒的奥司他韦敏感性
- Patent Title: Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses
- Patent Title (中): 具有抗流感活性的Zanamivir膦酸酯同系物并测定流感病毒的奥司他韦敏感性
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Application No.: US13697794Application Date: 2011-05-10
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Publication No.: US09403855B2Publication Date: 2016-08-02
- Inventor: Chi-Huey Wong , Jim-Min Fang , Yih-Shyun Edmund Cheng , Jiun-Jie Shie
- Applicant: Chi-Huey Wong , Jim-Min Fang , Yih-Shyun Edmund Cheng , Jiun-Jie Shie
- Applicant Address: TW
- Assignee: ACADEMIA SINICA
- Current Assignee: ACADEMIA SINICA
- Current Assignee Address: TW
- Agency: Duane Morris LLP
- International Application: PCT/US2011/035982 WO 20110510
- International Announcement: WO2011/143262 WO 20111117
- Main IPC: C07D309/28
- IPC: C07D309/28 ; C07F9/655 ; G01N33/569 ; A61K31/665 ; A61K31/683
Abstract:
Methods and compositions for detection of drug resistant pathogens and treatment against infections thereof are provided. Methods for detection of oseltamivir-resistant influenza viruses by competitive binding assays utilizing non-oseltamivir influenza virus neuraminidase inhibitors and oseltamivir carboxylate are provided. Influenza virus neuraminidase inhibitors coupled to sensors and useful for employment in the methods of the invention are disclosed. Novel phosphonate compounds active as neuraminidase inhibitors against wild-type and oseltamivir-resistant influenza strains of H1N1, H5N1 and H3N2 viruses are disclosed. An enantioselective synthetic route to preparation of these phosphonate compounds via sialic acid is provided.
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