Invention Grant
US09403869B2 α5β1 integrin binding RGD-lipopeptides with gene transfer activities
有权
α5β1整合素结合RGD-脂蛋白与基因转移活性
- Patent Title: α5β1 integrin binding RGD-lipopeptides with gene transfer activities
- Patent Title (中): α5β1整合素结合RGD-脂蛋白与基因转移活性
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Application No.: US12295107Application Date: 2007-03-30
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Publication No.: US09403869B2Publication Date: 2016-08-02
- Inventor: Bharat Kumar Majeti , Priya Prakash Karmali , Pramanik Dipankar , Arabinda Chaudhuri
- Applicant: Bharat Kumar Majeti , Priya Prakash Karmali , Pramanik Dipankar , Arabinda Chaudhuri
- Applicant Address: IN New Delhi
- Assignee: Council of Scientific and Industrial Research
- Current Assignee: Council of Scientific and Industrial Research
- Current Assignee Address: IN New Delhi
- Agency: Harness, Dickey & Pierce, PLC
- Priority: IN0924/DEL/2006 20060331
- International Application: PCT/IB2007/000826 WO 20070330
- International Announcement: WO2007/116276 WO 20071018
- Main IPC: A61K38/16
- IPC: A61K38/16 ; C07K5/11 ; A61K31/711 ; A61K31/7105 ; A61P35/00 ; A61K38/00 ; A61K48/00
Abstract:
The present invention provides synthesis of a novel series of cationic lipopeptides with integrin-binding RGD functionalities. The invention also provides high L27 (transformed S1 80, mouse sarcoma cells) cell tropic gene transfer properties of these novel RGD-lipopeptides. Since L27 cell surface contains over expressed integrins, the present class of lipopeptides with integrin-binding RGD ligands are likely to find future applications in targeting anti-cancer genes/drugs to the endothelial cells of tumor vasculatures (possessing over expressed integrins).
Public/Granted literature
- US20100234289A1 INTEGRIN BINDING RGD-LIPOPEPTIDES WITH GENE TRANSFER ACTIVITIES Public/Granted day:2010-09-16
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