Invention Grant
US09403899B2 Method for reducing the thromboembolic potential of a plasma-derived immunoglobulin composition
有权
用于降低血浆来源的免疫球蛋白组合物的血栓栓塞潜力的方法
- Patent Title: Method for reducing the thromboembolic potential of a plasma-derived immunoglobulin composition
- Patent Title (中): 用于降低血浆来源的免疫球蛋白组合物的血栓栓塞潜力的方法
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Application No.: US13595967Application Date: 2012-08-27
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Publication No.: US09403899B2Publication Date: 2016-08-02
- Inventor: Wolfgang Teschner , Harald Arno Butterweck , Bernhard Kölbl , Lucia Hofbauer , Hans-Peter Schwarz
- Applicant: Wolfgang Teschner , Harald Arno Butterweck , Bernhard Kölbl , Lucia Hofbauer , Hans-Peter Schwarz
- Applicant Address: IL Bannockburn CH Glattpark (Opfikon)
- Assignee: Baxalta Incorporated,Baxalta GmbH
- Current Assignee: Baxalta Incorporated,Baxalta GmbH
- Current Assignee Address: IL Bannockburn CH Glattpark (Opfikon)
- Agency: Morgan, Lewis & Bockius LLP
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K16/06
Abstract:
The present invention provides methods for reducing the amidolytic and anti-complement activity (ACA) content of an immunoglobulin composition through the use of cation exchange chromatography. In a specific embodiment, the invention provides methods for reducing the Factor XI and/or Factor XIa and/or ACA content of an immunoglobulin composition by collecting the leading portion of a cation exchange eluate. The present invention also provides immunoglobulin composition having reduced levels of amidolytic activity, Factor XI, and/or Factor XIa, and/or ACA content.
Public/Granted literature
- US20130058961A1 METHOD FOR REDUCING THE THROMBOEMBOLIC POTENTIAL OF A PLASMA-DERIVED IMMUNOGLOBULIN COMPOSITION Public/Granted day:2013-03-07
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