Invention Grant
US09404111B2 Inhibitors of miRNAs 221 and 222 for anti-tumor activity in multiple myeloma
有权
miRNA 221和222的抑制剂用于多发性骨髓瘤中的抗肿瘤活性
- Patent Title: Inhibitors of miRNAs 221 and 222 for anti-tumor activity in multiple myeloma
- Patent Title (中): miRNA 221和222的抑制剂用于多发性骨髓瘤中的抗肿瘤活性
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Application No.: US14798660Application Date: 2015-07-14
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Publication No.: US09404111B2Publication Date: 2016-08-02
- Inventor: Pierfrancesco Tassone , Pierosandro Tagliaferri , Maria Teresa Di Martino
- Applicant: Pierfrancesco Tassone , Pierosandro Tagliaferri , Maria Teresa Di Martino
- Agency: Stradley Ronon Stevens & Young, LLP
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04 ; A61K48/00 ; C12N15/113
Abstract:
Inhibitors of miRNAs 221 and 222, and their use as medicaments in the treatment of multiple myeloma. The inhibitors inhibit miRNAs 221 and 222 of the type of LNA-miRNAs and have the formula +C*A*G*+A*+C*A*+A*T*+G*T*+A*+G*C, and formula C*+A*+G*+A*T*+G*T*+A*+G*C wherein letters with symbol “+” indicate the positions of LNA and symbol “*” indicates phosphorothioate bonds.
Public/Granted literature
- US20150361433A1 INHIBITORS OF MIRNAS 221 AND 222 FOR ANTI-TUMOR ACTIVITY IN MULTIPLE MYELOMA Public/Granted day:2015-12-17
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