Invention Grant
US09404125B2 Transgenic animal for production of antibodies having minimal CDRs
有权
用于产生具有最小CDRs的抗体的转基因动物
- Patent Title: Transgenic animal for production of antibodies having minimal CDRs
- Patent Title (中): 用于产生具有最小CDRs的抗体的转基因动物
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Application No.: US14057820Application Date: 2013-10-18
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Publication No.: US09404125B2Publication Date: 2016-08-02
- Inventor: William Don Harriman , Robert Etches , Phil Leighton
- Applicant: Crystal Bioscience Inc.
- Applicant Address: US CA Emeryville
- Assignee: CRYSTAL BIOSCIENCE, INC.
- Current Assignee: CRYSTAL BIOSCIENCE, INC.
- Current Assignee Address: US CA Emeryville
- Agency: Bozicevic, Field & Francis LLP
- Agent James S. Keddie
- Main IPC: C12N15/85
- IPC: C12N15/85 ; A01K67/027 ; C07K16/00

Abstract:
A transgenic animal is provided. In certain embodiments, the transgenic animal comprises a genome comprising: an immunoglobulin light chain locus comprising: a) a functional immunoglobulin light chain gene comprising a transcribed variable region encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of 2 to 5 different amino acids; and ii. a light chain framework; and, operably linked to the functional immunoglobulin light chain gene: b) a plurality of pseudogene light chain variable regions each encoding: i. light chain CDR1, CDR2 and CDR3 regions that are composed of the same 2 to 5 different amino acids as the CDRs of the functional gene; and ii. a light chain framework that is identical in amino acid sequence to the light chain framework of the transcribed variable region.
Public/Granted literature
- US20140068796A1 TRANSGENIC ANIMAL FOR PRODUCTION OF ANTIBODIES HAVING MINIMAL CDRS Public/Granted day:2014-03-06
Information query
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