Invention Grant
- Patent Title: Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof
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Application No.: US14514718Application Date: 2014-10-15
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Publication No.: US09404129B2Publication Date: 2016-08-02
- Inventor: Michael Katz , Hans Peter Smits , Jochen Forster , Jens Bredel Nielsen
- Applicant: Evolva SA
- Applicant Address: CH Reinach
- Assignee: Evolva SA
- Current Assignee: Evolva SA
- Current Assignee Address: CH Reinach
- Agency: McDonnell Boehnen Hulbert & Berghoff LLP
- Priority: GB0503657.9 20050222
- Main IPC: C12N1/20
- IPC: C12N1/20 ; C12N1/00 ; C12P7/22 ; C07H21/04 ; C12P23/00 ; C12N9/10 ; C12N9/02 ; C12N9/88 ; C12N9/00 ; C12N15/52 ; C12P7/42 ; A23C3/08 ; A61K31/05
Abstract:
A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (PAL) produces trans-cinnamic acid from phenylalanine, cinnamate 4-hydroxylase (C4H) produces 4-coumaric acid from said trans-cinnamic acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA, or in which L-phenylalanine- or tyrosine-ammonia lyase (PAL/TAL) produces 4-coumaric acid, 4-coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA. The micro-organism may be a yeast, fungus or bacterium including Saccharomyces cerevisiae, E. coli, Lactococcus lactis, Aspergillus niger, or Aspergillus oryzae.
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