A spectroscopic measurement system, which may utilize multiple plasmonic filters associated with a cuvette to monitor different wavelengths of light. The spectroscopic measurement system may measure absorbance and or fluorescence, and may have built-in low cost CMOS image sensor(s). Reagents and samples may be introduced to the cuvette from a fluidics manifold. Multiple sets of combined cuvettes, image sensors and plasmonic filters may utilize a single fluidics manifold for reagent and sample distribution.