A touch screen driving device includes a touch screen including Tx channels, Rx channels, and sensor nodes formed at crossings of the Tx channels and the Rx channels, a Tx driving circuit supplying a Tx driving pulse to the Tx channels, sensing units sampling voltages of the sensor nodes supplied through the Rx channels, a multiplexer (mux) array including mux switches, each of which is cross-coupled with output terminals of the sensing units adjacent to each mux switch, an analog-to-digital converter converting an analog sampling signal received from the mux array into digital data, an average unit which averages the digital data and removes noise included in the digital data, and a touch controller which analyzes the digital data, in which the noise is removed, using a touch recognition algorithm and outputs touch data including coordinate information of a touch position.