A method for image registration includes the steps of: providing a computer and an imager; acquiring and processing a reference image frame including a plurality of reference strips; acquiring and correcting a target frame by the steps of: acquiring one or more target frame strips of the target frame; comparing the one or more target frame strips in real-time to one or more corresponding strips of the reference frame based on a calculated registration of a specific target frame strip from a previous target frame; correcting a registration of the one or more target frame strips; repeating steps until a last strip of the target frame; repeating the steps of acquiring and correcting a target frame until a last target frame is acquired; and saving processed image based on a plurality of corrected target frames to a non-volatile memory. A system to perform the method is also described.