An integrated circuit includes a circuit and a guard ring. The circuit is over a substrate. The guard ring surrounds the circuit and includes a staggered line. The staggered line comprises a first zigzag line and a second zigzag line. The first zigzag line comprises interconnections formed in at least two GDS layers. The second zigzag line comprises interconnections formed in at least two GDS layers. The first zigzag line and the second zigzag line form a first quadrangle and a second quadrangle.