A connection device with electrostatic discharge protection includes a first interface including a plurality of signal pins for electrically connecting to a first electronic device, a second interface including a plurality of signal pins for electrically connecting to a second electronic device, a driving circuit coupled to a first signal pin of the plurality of signal pins of the first interface for generating a control signal according to a signal of the first signal pin, and a switch circuit coupled to the first interface, the second interface, and the driving circuit for controlling a conduction situation between the plurality of signal pins of the first interface and the plurality of signal pins of the second interface.